Synthesis and release profile of ibuprofen-loaded zein and gelatin nanofiber scaffolds for potential transdermal application in burn wound treatment

umaima saleem memon; Murk saleem memon; Abdul Wahab Memon; Mehwish Shahzad; Murk Rehman; Farooq Ahmed; Zeeshan Khatri

doi:10.22581/muet1982.3372

umaima saleem memon Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro, Pakistan
Murk saleem memon Institute of Biomedical Engineering and Technology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Abdul Wahab Memon Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro, Pakistan
Mehwish Shahzad Department of Chemistry, Istanbul Technical University, Istanbul, Turkey
Murk Rehman Institute of Biomedical Engineering and Technology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Farooq Ahmed Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro, Pakistan
Zeeshan Khatri Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro, Pakistan

DOI: https://doi.org/10.22581/muet1982.3372

Abstract

An antimicrobial barrier may accelerate rehabilitation by facilitating the healing of living tissues affected by injuries caused by burning. Fibrous mats based on nanotechnology have been extensively researched for their potential as drug delivery systems. The fabrication of electrospun polymeric nanofibrous mats containing non-steroidal anti-inflammatory medications (NSAIDs) and antibacterial agents has been discussed in this article. Electrospinning has been employed to create nanofibrous mats from pure zein and pure gelatin, and their combined use with Ibuprofen, an NSAID. Due to the ability of these electrospun nanofibrous mats to control exudation, they keep the site dry and shield it from microbiological activity, which makes them a good option for wound healing. In addition to providing an antibacterial layer that promotes wound healing, the manufactured mats can also function as medicine transporters. This research article extensively addresses the drug release profile from the carrier nanofibrous mats and the characteristics of fiber mats using standard characterization techniques like Fourier-transform infrared spectroscopy (FTIR) and Scanning electron microscope (SEM). The resultant fiber mats' drug release kinematics are compared to the standard mathematical models (Korsmeyer-pappas and Higuchi. The cumulative drug percentage released from these mats consistently validated Higuchi’s model, which exhibited diffusion-controlled super case-II transport (n>1). The results indicate that the Ibuprofen is efficiently loaded onto the nanofibers, with a uniform distribution of the drug throughout the fiber matrix and ensures that the drug is released in a controlled and sustained manner, promoting effective wound healing.