Entrepreneur is known as a person who believes in hardworking in his entire period of life. Rest and respite for entrepreneurs seem unacceptable and are treated as enemy of entrepreneur's success. Entrepreneur is constantly involved in thinking for growth and prosperity of his/her business venture. For this he/she tries to gain the secrets of business success. As a result, this research explores few of the secrets of success in the life of every individual. These secrets are recognized as basic qualities or attributes of entrepreneurs which bring them from bottom to top. There are many qualities, some of the key attributes are: innovativeness, risk taking, confidence, commitment and decision making. These qualities of entrepreneurs were investigated by evaluating the performance of entrepreneurs in SME (Small and Medium Enterprise) in province of Sindh, Pakistan. Performance indicators were considered as investment/worker and sales turnover/worker. For analyzing the data, statistical tools such as mean, standard deviation and coefficient of correlation (r) were computed. SPSS and Excel Softwares were used. One way ANNOVA was also used to work out F-value to examine significance of data/variance among groups. Results show positive relationship between qualities of entrepreneurs and their performance. Empirical evidence suggests proportional increase of entrepreneurial qualities with increase in performance.